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In Cohort 1, 25 WT and 25 RAMP1/3 KO male mice aged 1220 weeks old were injected intraperitoneally after a 12-hour fast with vehicle, sCT at doses of 3 or 150 nmol/kg, or Cagrilintide at a dose of3 nmol/kg

In the presence of specific ferroptosis-inducing agents, baicalein exhibited superior anti-ferroptosis activity compared to established ferroptosis inhibitors such as ferrostatin-1, liproxstatin-1, desferrioxamine mesylate, and -mercaptoethanol (71, 74)